6Are there genome size limits for an icosahedral capsid geometry? One of the largest known viruses with a true icosahedral capsid is Megavirus chilensis with a genome of 1.26 MB and capsid size of ~440 nm. Mimiviruses also have genomes in the same range and icosahedral capsids of 200-400 nm surrounded by a fibrous layer. But even larger viruses, such as Pandoraviruses (2.5+ MB genome) and Pithoviruses (~1.5 μm capsid size) have alternative, more unusual morphologies to accommodate their large genomes.
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